ผู้ช่วยศาสตราจารย์ ดร.ทนพ.เทวิน เทนคำเนาว์

Education

• B.S. (Medical Technology, Honors), 1994, Chulalongkorn University, Bangkok, THAILAND
• Ph.D. (Biochemistry and Molecular Biophysics), 2001, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia, USA

Training

• 2001-2002, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA

Professional Experience

• ผู้ช่วยคณบดีฝ่ายกิจการนิสิต และเทคโนโลยีสารสนเทศ (2546)
• ผู้ช่วยคณบดีฝ่ายบริการวิชาการ (2546-2547)
• ผู้ช่วยคณบดีฝ่ายเทคโนโลยีสารสนเทศ (2548-2551)
• ผู้ช่วยคณบดีฝ่ายวิจัย (1 กันยายน 2551 – 31 สิงหาคม 2555)
• หัวหน้าภาควิชาเคมีคลินิก วาระที่ 1 (1 เมษายน 2552-31 มีนาคม 2556)
• หัวหน้าภาควิชาเคมีคลินิก วาระที่ 2 (1 เมษายน 2556-31 มีนาคม 2560)
• ประธานคณะกรรมการบริหารหลักสูตรวิทยาศาสตรมหาบัณฑิตและดุษฎีบัณฑิต สาขาวิชาชีวเคมี คลินิกและอณูทางการแพทย์ (1 มิถุนายน 2560 – พฤษภาคม 2564)
• กรรมการบริหารหลักสูตรวิทยาศาสตรดุษฎีบัณฑิต สาขาวิชาชีวเวชศาสตร์ (สหสาขาวิชา) บัณฑิตวิทยาลัย (2544-ปัจจุบัน)
• ประธานคณะกรรมการบริหารหลักสูตรวิทยาศาสตรบัณฑิต สาขาวิชาเทคนิคการแพทย์ (พฤษภาคม 2564-ปัจจุบัน)
• กรรมการดำเนินงานโครงการรับนักเรียนจากชนบทเข้าศึกษาในจุฬาลงกรณ์ มหาวิทยาลัย (2551-ปัจจุบัน)

Publications

Asst.Prof.Dr. Tewin Tencomnao published more than 152 articles in the Scopus database with h- index = 26 and more than 7,200 citations. Most recent publications are shown below.

1. Prasanth MI, Prasansuklab A, Verma K, Brimson JM, Malar DS, Tencomnao T. Hylocereus undatus extends lifespan and exerts neuroprotection in Caenorhabditis elegans via DAF-16 mediated pathway. Nutrition and Healthy Aging. 2023.
2. Asmara AP, Prasansuklab A, Tencomnao T, Ung AT. Identification of Phytochemicals in Bioactive Extracts of Acacia saligna Growing in Australia. Molecules. 2023; 28(3):1028.
3. Theerasri A, Janpaijit S, Tencomnao T, Prasansuklab A. Beyond the classical amyloid hypothesis in Alzheimer’s disease: Molecular insights into current concepts of pathogenesis, therapeutic targets, and study models. WIREs Mech Dis. 2023;15(2):e1591.
4. Alugoju P, Vishnu Bhandare V, S. Patil V et al. In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease. F1000Research. 2023, 12:230.
5. Malar DS, Thitilertdecha P, Ruckvongacheep KS, Brimson S, Tencomnao T, Brimson JM. Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders. CNS Drugs. 2023.
6. Prasanth MI, Brimson JM, Tencomnao T. Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS COV-2. Expert Opinion on Therapeutic Targets. 2023.
7. Prasansuklab A, Sukjamnong S, Theerasri A, Hu VW, Sarachana T, Tencomnao T. Transcriptomic analysis of glutamate induced HT22 neurotoxicity as a model for screening anti Alzheimer’s drugs. Scientific reports. 2023(13):7225.
8. Janpaijit S, Sillapachaiyaporn C, Theerasri A, Charoenkiatkul S, Sukprasansap M, Tencomnao T. Cleistocalyx nervosum var. paniala Berry Seed Protects against TNF-α-Stimulated Neuroinflammation by Inducing HO-1 and Suppressing NF-κB Mechanism in BV-2 Microglial Cells. Molecules. 2023(28):7.
9. Malar DS, Prasanth MI, Brimson JM, Verma K, Tencomnao T. Neuroprotective effect of Hibiscus sabdariffa extract against high glucose-induced toxicity in Neuro-2a cells and Caenorhabditis elegans. Nutrition and Healthy Aging. 2023.
10. Mongkolpobsin K, Sillapachaiyaporn C, Lertpatipanpong P, Boonruang K, Hwang CY, Tencomnao T, Baek SJ. Cold atmospheric microwave plasma (CAMP) stimulates dermal papilla cell proliferation by inducing β catenin signaling. Scientific reports. 2023; 13:3089.
11. Mongkolpobsin K, Sillapachaiyaporn C, Nilkhet S, Tencomnao T, Baek SJ. Stigmasterol isolated from Azadirachta indica flowers attenuated glutamate-induced neurotoxicity via downregulation of the Cdk5/p35/p25 signaling pathway in the HT-22 cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2023; 113(3):154728
12. Sillapachaiyaporn C, Mongkolpobsin K, Chuchawankul S, Tencomnao T, Baek SJ. Neuroprotective effects of ergosterol against TNF-α-induced HT-22 hippocampal cell injury. Biomedicine & pharmacotherapy. Biomedecine & pharmacotherapie. 2022;154(3):113596.
13. Brimson JM, Prasanth MI, Kumaree KK, Thitilertdecha P, Malar DS, Tencomnao T, Prasansuklab A. Tea Plant (Camellia sinensis): A Current Update on Use in Diabetes, Obesity, and Cardiovascular Disease. Nutrients. 2022 Dec 21;15(1):37.
14. Brimson JM, Prasanth MI, Malar DS, Verma K, Plaingam W, Tencomnao T. Bacopa monnieri protects neuronal cell line and Caenorhabditis elegans models of Alzheimer’s disease through sigma-1 receptor antagonist sensitive and antioxidant pathways. Nutrition and Healthy Aging. 2022.
15. Malar DS, Prasanth MI, Verma K, Prasansuklab A, Tencomnao T. Hibiscus sabdariffa Extract Protects HaCaT Cells against Phenanthrene-Induced Toxicity through the Regulation of Constitutive Androstane Receptor/Pregnane X Receptor Pathway. Nutrients. 2022;14(18):3829.
16. Pattarachotanant N, Sornkaew N, Warayanon W, Rangsinth P, Sillapachaiyaporn C, Vongthip W, Chuchawankul S, Prasansuklab A, Tencomnao T. Aquilaria crassna Leaf Extract Ameliorates Glucose-Induced Neurotoxicity In Vitro and Improves Lifespan in Caenorhabditis elegans. Nutrients. 2022;14:3668.
17. Saeliw T, Permpoon T, Ladsee N, Tencomnao T, Hu VW, Sarachana T, Green D, Sae-Lee C. LINE 1 and Alu methylation signatures in autism spectrum disorder and their associations with the expression of autism related genes. Scientific reports. 2022;12:13970.
18. Cao S-Q, Aman Y, Fang, EF, Tencomnao T. P. edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer’s Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway. Molecular Neurobiology. 2022; 59(9):1-18
19. Chaikhong K, Chumpolphant S, Rangsinth P, Sillapachaiyaporn C, Chuchawankul S, Tencomnao T, Prasansuklab A. Antioxidant and Anti-Skin Aging Potential of Selected Thai Plants: In Vitro Evaluation and In Silico Target Prediction. Plants. 2022; 12:65.
20. Janpaijit S, Lertpatipanpong P, Sillapachaiyaporn C, Baek SJ, Charoenkiatkul S, Tencomnao T, Sukprasansap M. Anti-neuroinflammatory effects of Cleistocalyx nervosum var. paniala berry-seed extract in BV-2 microglial cells via inhibition of MAPKs/NF-κB signaling pathway. Heliyon. 2022;8:e11869.
21. Nantacharoen W, Baek SJ, Plaingam W, Charoenkiatkul S, Tencomnao T, Sukprasansap M. Cleistocalyx nervosum var. paniala Berry Promotes Antioxidant Response and Suppresses Glutamate-Induced Cell Death via SIRT1/Nrf2 Survival Pathway in Hippocampal HT22 Neuronal Cells. Molecules. 2022;27:5813.
22. Zhang S, Duangjan C, Tencomnao T, Wu L, Wink M, Lin J. Oolonghomobisflavans exert neuroprotective activities in cultured neuronal cells and anti-aging effects in Caenorhabditis elegans. Front. Aging Neurosci. 2022;14:967316
23. Lordumrongkiat, N., Chotechuang, N., Prasanth, M.I., Jindatip, D., Ma-on, C., Chuenwisad, K., Leelahavanichkul, A., Tencomnao, T., Boonla, C. HydroZitLa inhibits calcium oxalate stone formation in nephrolithic rats and promotes longevity in nematode Caenorhabditis elegans (2022) Scientific Reports, 12 (1), art. no. 5102.
24. Chumpolphant, S., Suwatronnakorn, M., Issaravanich, S., Tencomnao, T., Prasansuklab, A. Polyherbal formulation exerts wound healing, anti-inflammatory, angiogenic and antimicrobial properties: Potential role in the treatment of diabetic foot ulcers (2022) Saudi Journal of Biological Sciences, 29 (7), art. no. 103330.
25. Sillapachaiyaporn, C., Chuchawankul, S., Nilkhet, S., Moungkote, N., Sarachana, T., Ung, A.T., Baek, S.J., Tencomnao, T. Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation (2022) Food Research International, 157, art. no. 111433.
26. Rakkhittawattana, V., Panichayupakaranant, P., Prasanth, M.I., Brimson, J.M., Tencomnao, T. Rhinacanthin-C but Not-D Extracted from Rhinacanthus nasutus (L.) Kurz Offers Neuroprotection via ERK, CHOP, and LC3B Pathways (2022) Pharmaceuticals, 15 (5), art. no. 627.
27. Sivamaruthi, B.S., Prasanth, M.I., Kesika, P., Tencomnao, T., Chaiyasut, C. Functional properties of Streblus asper Lour.: a review (2022) Food Science and Technology (Brazil), 42, art. no. e113421.
28. Cao, S.-Q., Aman, Y., Fang, E.F., Tencomnao, T. P. edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer’s Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway (2022) Molecular Neurobiology.
29. Alugoju, P., Krishna Swamy, V.K.D., Anthikapalli, N.V.A., Tencomnao, T. Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review (2022) Critical Reviews in Food Science and Nutrition.
30. Thongkorn, S., Kanlayaprasit, S., Panjabud, P., Saeliw, T., Jantheang, T., Kasitipradit, K., Sarobol, S., Jindatip, D., Hu, V.W., Tencomnao, T., Kikkawa, T., Sato, T., Osumi, N., Sarachana, T. Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions (2021) Scientific Reports, 11 (1), art. no. 1241.
31. Brimson, J.M., Brimson, S., Prasanth, M.I., Thitilertdecha, P., Malar, D.S., Tencomnao, T. The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data (2021) Scientific Reports, 11 (1), art. no. 596.
32. Vongthip, W., Sillapachaiyaporn, C., Kim, K.-W., Sukprasansap, M., Tencomnao, T. Thunbergia laurifolia leaf extract inhibits glutamate-induced neurotoxicity and cell death through mitophagy signaling (2021) Antioxidants, 10 (11), art. no. 1678.
33. Sillapachaiyaporn, C., Rangsinth, P., Nilkhet, S., Ung, A.T., Chuchawankul, S., Tencomnao, T. Neuroprotective effects against glutamate-induced ht-22 hippocampal cell damage and caenorhabditis elegans lifespan/healthspan enhancing activity of auricularia polytricha mushroom extracts (2021) Pharmaceuticals, 14 (10), art. no. 1001.
34. Brimson, J.M., Prasanth, M.I., Malar, D.S., Thitilertdecha, P., Kabra, A., Tencomnao, T., Prasansuklab, A. Plant polyphenols for aging health: Implication from their autophagy modulating properties in age-associated diseases (2021) Pharmaceuticals, 14 (10), art. no. 982.
35. Rangsinth, P., Duangjan, C., Sillapachaiyaporn, C., Isidoro, C., Prasansuklab, A., Tencomnao, T. Caesalpinia mimosoides leaf extract promotes neurite outgrowth and inhibits bace1 activity in mutant app-overexpressing neuronal neuro2a cells (2021) Pharmaceuticals, 14 (9), art. no. 901.
36. Duangjan, C., Rangsinth, P., Zhang, S., Gu, X., Wink, M., Tencomnao, T. Neuroprotective effects of Glochidion zeylanicum leaf extract against h2 o2 /glutamate-induced toxicity in cultured neuronal cells and aβ induced toxicity in Caenorhabditis elegans (2021) Biology, 10 (8), art. no. 800.
37. Pattarachotanant, N., Prasansuklab, A., Tencomnao, T. Momordica charantia l. Extract protects hippocampal neuronal cells against PAHs-induced neurotoxicity: Possible active constituents include stigmasterol and vitamin e (2021) Nutrients, 13 (7), art. no. 2368.

Book chapters

1. Phaniendra Alugoju and Tewin Tencomnao. Phytochemical Constituents, Antidiabetic Potential and Other Pharmacological Activities of Mulberry (Morus alba L.). July 20, 2023, 345-362. CRC Press. Book Title: Antidiabetic Medicinal Plants and Herbal Treatments. 1st Edition. Edited By Azamal Husen. ISBN 9781032386263.
2. Phaniendra Alugoju and Tewin Tencomnao. Lignosus rhinocerus (Tiger’s Milk Mushroom). Book Title: Mushrooms: Nutraceuticals and Functional. CRC Press; 1st edition (April 3, 2023). ISBN-13:‎978-1032344539.
3. Phaniendra Alugoju and Tewin Tencomnao. “Medicinal Plants Proteomics in response to Abiotic stresses”. Book Title: Medicinal Plants. Springer Nature. 1st edition. 31 Jan 2023. ISBN-13:9789811956102.
4. Prasanth MI, Thitilertdecha P, Malar DS, Tencomnao T, Prasansuklab A, Brimson JM (2022). Nardostachys jatamansi (Spikenard) and Ocimum tenuiflorum (Holy Basil). In Book: Herbs, Shrubs, and Trees of Potential Medicinal Benefits. p. 163-178 (Publisher: CRC Press).
5. Malar DS, Prasanth MI, Tencomnao T, Brimson JM, Prasansuklab A (2022). Garcinia indica (Kokum) and Ilex aquifolium (European Holly). In Book: Herbs, Shrubs, and Trees of Potential Medicinal Benefits. p. 427-446 (Publisher: CRC Press).
6. Phaniendra Alugoju, K.K Kumaree, Anchalee Prasansuklab and Tewin Tencomnao. Melatonin as a vital metabolite in medicinal and food plants. Book Title: Advancement of melatonin research in plants: multi-faceted role in regulating development and stress protection. 2022 (CRC Press Taylor & Francis) (Accepted).
7. Phaniendra Alugoju and Tewin Tencomnao. “Production and Role of Plants Secondary Metabolites under Various Environmental Pollution.” Book Title: Elsevier. 1st Edition. November 4, 2022. eBook ISBN: 9780323983099.
8. Prasanth MI, Malar DS, Kesika P, Tencomnao T, Sivamaruthi BS, “Impact of probiotic supplementation and the role of gut microbiome in obesity” Chapter 15, Pages, 297-319. In “Probiotics: Advanced Food and Health Applications”. Adriano Brandelli. Elsevier Academic Press Inc. London, UK (2022)
9. Tencomnao T, Theerasri A & Janpaijit S. “Mechanisms of anti-glutamate neurotoxicity of botanicals and their chemical constituents” Chapter X, Pages, 359-369. In “BenthamBriefs in Biomedicine and Pharmacotherapy: Oxidative Stress and Natural Antioxidants (Volume 1)”. Kaur P, Mehta RG, Robin, Thind TS & Arora S. Bentham Science Publishers. Singapore (2021)
10. Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Pulikkottil Stanes Rosmol, Tewin Tencomnao. “Unraveling the mode of action of medicinal plants in delaying age-related diseases using model organisms” Chapter 2, Pages, 37-60. In “Medicinal and Aromatic Plants: Expanding their Horizons through Omics”. Tariq Aftab, Khalid Rehman Hakeem. Elsevier Academic Press Inc. London, UK (2021)
11. J. M. Brimson, T. Tencomnao. “Rhinacanthus Nasutus Extract as a Neuroprotectant” Chapter 9, Pages, 77-84. In “Bioactive Nutracuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy”. R. Watson, V. Preedy. Elsevier Academic Press Inc. London, UK (2014)

Research awards

1. In 2021, a recipient of Fulbright grant award as a Thai Visiting Scholar to conduct research in USA (Department of Physiology, College of Medicine, University of Kentucky).
2. In 2020, a recipient of outstanding researcher award of Chulalongkorn University
3. In 2015, a recipient of DMSc Award from Department of Medical Sciences, Ministry of Public Health, Thailand. for his outstanding research entitled Anti-neuroprotective effects and underlying mechanisms of Rhinacanthus nasutus extracts.
4. In 2015, a recipient of the gold award in the field of innovation from Universiti Malaysia Perlis, Malaysia in International Engineering Invention & Innovation Exhibition (i-ENVEX) based on the research work entitled Anti-aging cream with natural resveratrol from Perlis grapevine.